2004擭乮暯惉16擭乯

榑暥

1:	Tokino T.	Related Articles, Substance (MeSH Keyword), LinkOut
	Dual role of p53 in DNA binding. Cancer Biol Ther. 2004 Dec;3(12):1322-3. Epub 2004 Dec 20. No abstract available. PMID: 15662136 [PubMed - indexed for MEDLINE]

2:	Murata M, Kojima T, Yamamoto T, Go M, Takano K, Chiba H, Tokino T, Sawada N.	Related Articles, GENSAT, Gene, Gene (GeneRIF), HomoloGene, Nucleotide, Nucleotide (RefSeq), OMIM (calculated), Protein (RefSeq), Protein (Weighted), Substance (MeSH Keyword), Taxonomy via GenBank, UniGene, Protein, GEO Profiles, Cited in PMC, LinkOut
	Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis. Cell Tissue Res. 2005 Feb;319(2):341-7. Epub 2004 Nov 19. PMID: 15558322 [PubMed - indexed for MEDLINE]

3:	Satoh A, Toyota M, Ikeda H, Morimoto Y, Akino K, Mita H, Suzuki H, Sasaki Y, Kanaseki T, Takamura Y, Soejima H, Urano T, Yanagihara K, Endo T, Hinoda Y, Fujita M, Hosokawa M, Sato N, Tokino T, Imai K.	Related Articles, Compound (MeSH Keyword), Gene, Gene (GeneRIF), HomoloGene, Nucleotide (RefSeq), Protein (RefSeq), Protein (Weighted), Substance (MeSH Keyword), Taxonomy via GenBank, UniGene, GEO Profiles, Cited in PMC, LinkOut
	Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells. Oncogene. 2004 Nov 25;23(55):8876-86. PMID: 15467734 [PubMed - indexed for MEDLINE]

4:	Ueno M, Toyota M, Akino K, Suzuki H, Kusano M, Satoh A, Mita H, Sasaki Y, Nojima M, Yanagihara K, Hinoda Y, Tokino T, Imai K.	Related Articles, Taxonomy via GenBank, Prot ein, Cited in PMC, LinkOut
	Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer. Tumour Biol. 2004 May-Jun;25(3):134-40. PMID: 15361710 [PubMed - indexed for MEDLINE]

5:	Adachi K, Toyota M, Sasaki Y, Yamashita T, Ishida S, Ohe-Toyota M, Maruyama R, Hinoda Y, Saito T, Imai K, Kudo R, Tokino T.	Related Articles, GENSAT, Gene, Gene (GeneRIF), HomoloGene, Nucleotide, Nucleotide (RefSeq), Protein (RefSeq), Protein (Weighted), Taxonomy via GenBank, UniGene, Protein, GEO Profiles, Cited in PMC, LinkOut
	Identification of SCN3B as a novel p53-inducible proapoptotic gene. Oncogene. 2004 Oct 14;23(47):7791-8. PMID: 15334053 [PubMed - indexed for MEDLINE]

6:	Terasawa K, Sagae S, Toyota M, Tsukada K, Ogi K, Satoh A, Mita H, Imai K, Tokino T, Kudo R.	Related Articles, Gene, Gene (GeneRIF), HomoloGene, Nucleotide (RefSeq), Protein (RefSeq), Protein (Weighted), Substance (MeSH Keyword), Taxonomy via GenBank, UniGene, GEO Profiles, Cited in PMC, LinkOut
	Epigenetic inactivation of TMS1/ASC in ovarian cancer. Clin Cancer Res. 2004 Mar 15;10(6):2000-6. PMID: 15041718 [PubMed - indexed for MEDLINE]

7:	Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB.	Related Articles, Gene (OMIM), OMIM (calculated), OMIM (cited), Protein (Weighted), Substance (MeSH Keyword), Cited in PMC, LinkOut
	Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet. 2004 Apr;36(4):417-22. Epub 2004 Mar 14. PMID: 15034581 [PubMed - indexed for MEDLINE]

8:	Morimoto Y, Toyota M, Satoh A, Murai M, Mita H, Suzuki H, Takamura Y, Ikeda H, Ishida T, Sato N, Tokino T, Imai K.	Related Articles, OMIM (calculated), Substance (MeSH Keyword), Cited in PMC, LinkOut
	Inactivation of class II transactivator by DNA methylation and histone deacetylation associated with absence of HLA-DR induction by interferon-gamma i n haematopoietic tumour cells. Br J Cancer. 2004 Feb 23;90(4):844-52. Erratum in: Br J Cancer. 2004 Nov 29;91(11):1978. PMID: 14970863 [PubMed - indexed for MEDLINE]

9:	Takamura Y, Ikeda H, Kanaseki T, Toyota M, Tokino T, Imai K, Houkin K, Sato N.	Related Articles, OMIM (calculated), LinkOut
	Regulation of MHC class II expression in glioma cells by class II transactivator (CIITA). Glia. 2004 Mar;45(4):392-405. PMID: 14966870 [PubMed - indexed for MEDLINE]

憤丂愢

1. 楅栘戱, 朙揷幚, 帪栰棽帄, 崱堜峗嶰. SFRP堚揱巕偺僄僺僕僃僱僥傿僢僋側晄妶惈壔偼僸僩戝挵娻偵偍偗傞Wnt僔僌僫儖宱楬偺帩懕揑妶惈壔傪曗姰偡傞. 嵶朎岺妛 2004, 23: 674-675.

妛夛敪昞

1. Tokino T, Sasaki Y. In vitro and in vivo adenovirus-mediated p53 family tumor suppressor therapy in haman cancer. 6th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association. 2004, Hawaii, USA.
2. Toyota M, Satoh A, Akino K, Ogi K, Tokino T, Imai K. DNA methylation and gastrointestinal malignancies: Functional consequences and clinical implications. 6th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association. 2004, Hawaii.
3. Ogi K, Toyota M, Mita H, Satoh A, Hiratsuka H, Imai K, Tokino T. Aberrant methylation of CHFR, a mitotic checkpoint gene, and sensitivity to microtubule inhibitors in oral squamous cell carcinoma. 6th Joint Conference of the American Association for Cancer research and the Japanese Cancer Association. 2004, Hawaii.
4. Sasaki Y, Mita H, Toyota M, Imai K, Nakamura Y, Tokino T. Identification of the interleukin-4 receptor 兛 gene as a direct target for p73. 6th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association. 2004, Hawaii.
5. Akino K, Imai K, Maruyama R, Mita H, Suzuki H, Tokino T, Toyota M. K-ras/Ras effector alterations in colorectal cancers. 95 th Annual Meeting of American Association for Cancer Research. 2004, Florida.
6. Tokino T, Sasaki Y, Mita H, Toyota M, Yamashita T, Imai K, Nakamura Y. Identification of the interleukin-4 receptor alpha gene as a direct target for p73. 95 th Annual Meeting, American Association for Cancer Research. 2004, Florida.
7. Toyota M, Satoh A, Morimoto Y, Akino K, Mita H, Maruyama R, Suzuki H, Tokino T, Imai K. Epigenetic inactivation of transactivator of class II associated with absence of HLA-DR in colorectal and gastric cancer cells. 95 th Annual Meeting, American Association for Cancer Research. 2004, Florida.
8. Mita H, Toyota M, Satoh A, Ogi K, Sasaki Y, Naishiro Y, Akino K, Imai K, Tokino T. Functional analysis of checkpoint ligase CHFR under mitotic stress. 95 th Annual Meeting, American Association for Cancer Research. 2004, Florida.
9. Maruyama R, Toyota M, Aoki F, Sasaki Y, Mita H, Akino K, Akashi H, Tatsumi H, Imai K, Tokino T. Identification of p53 target sequences by network parallel computing. 95 th Annual Meeting, American Association for Cancer Research. 2004, Florida.
10. Okuda H, Toyota M, Tokino T, Shuin T. Promoter hypermethylation of multiple genes in renal cell carcinoma. 95 th Annual Meeting, American Association for Cancer Research. 2004, Florida.
11. Sasaki Y, Naishiro Y, Mita H, Toyota M, Imai K, Nakamura Y, Tokino T. Isolation of target genes regulated by p53 family transcription factors. An AACR Special Conference in Cancer Research. Advances in Proteomics in Cancer Research. 2004, Florida.
12. Toyota M, Suzuki H, Satoh A, Morimoto Y, Tokino T, Imai K. Epigenetic inactivation of transactivator of MHC class II associated with absence of HLA-DR in colorectal and gastric cancer cells. The XXXII Meeting of the International Society for Oncodevelopmental Biology and Medicine. 2004, Helsinki.
13. Toyota M, Kusano M, Suzuki H, Akino K, Nojima M, Tokino T, Imai K. Methylation clustering analysis identified distinct genetic profiles and etiological association in gastric cancer. An AACR Special Conference in Cancer Research. 2004, Hawaii.
14. Kashima L, Mita H, Toyota M, Satoh A, Ogi K, Sasaki Y, Naishiro Y, Kimishige Akino, Imai K, Tokino T. Functional analysis of checkpoint ligase CHFR under mitotic stress. 戞屲夞暥晹壢妛徣摿掕椞堟尋媶乽偑傫乿5椞堟庒庤尋媶儚乕僋僔儑僢僾. 2004, 澍壢丏
15. 廐栰岞恇丆朙揷幚丆帪栰棽帄丏戝挵偑傫偵偍偗傞RAS僔僌僫儖揱払堎忢偺夝愅丏戞90夞擔杮徚壔婍昦妛夛憤夛丏2004丆愬戜丏
16. 楅栘戱丆朙揷幚丆帪栰棽帄丆崱堜峗嶰丏戝挵娻偵偍偗傞暘斿宆Frizzled娭楢抈敀堚揱巕偺儊僠儖壔偲Wnt僔僌僫儖宱楬惂屼偺夝愅丏戞8夞偑傫暘巕昗揑帯椕尋媶夛憤夛丏2004丆幁帣搰丏
17. 朙揷幚丆楅栘戱丆帪栰棽帄丆崱堜峗嶰丏M婜僠僃僢僋億僀儞僩堚揱巕CHFR偺堎忢儊僠儖壔偲旝彫娗慾奞嵻姶庴惈丏戞8夞偑傫暘巕昗揑帯椕尋媶夛憤夛丏2004丆幁帣搰丏
18. 楅栘戱丆朙揷幚丆帪栰棽帄丆怷丂枮丆崱堜峗嶰丏僄僺僕僃僱僥傿僢僋側堎忢傪巜昗偲偟偨怴婯戝挵娻娭楢堚揱巕偺僗僋儕乕僯儞僌丏戞15夞擔杮徚壔婍娻敪惗妛夛憤夛丏2004, 嶥杫丏
19. 廐栰岞恇丆朙揷幚丆楅栘戱丆憪栰恀挩丆帪栰棽帄丆崱堜峗嶰丏RAS僔僌僫儖揱払偵偍偗傞Genetic/Epigenetic堎忢偺夝愅丏戞15夞擔杮徚壔婍娻敪惗妛夛憤夛丏2004丆嶥杫丏
20. 娵嶳楁弿丆朙揷幚丆柧愇峗巎丆惵栘暥晇丆嵅乆栘懽巎丆尒揷桾復丆昪戙峃壜丆奯撪塸庽丆扖枻帯擵丆帪栰棽帄丆崱堜峗嶰丏僎僲儉忣曬傪棙梡偟偨栐梾揑夝愅偵傛傞怴婯p53昗揑堚揱巕摨掕偺帋傒丏戞15夞擔杮徚壔婍娻敪惗妛夛憤夛丏2004丆嶥杫丏
21. 懞堜惌巎丆朙揷幚丆嵅摗垷桼旤丆忋栰棟巕丆廐栰岞恇丆楅栘戱丆尒揷桾復丆帪栰棽帄丆崱堜峗嶰丏傾億僩乕僔僗桿摫堚揱巕BNIP3偺僄僺僕僃僱僥傿僢僋側堎忢偲徚壔婍娻偵偍偗傞Hypoxia掞峈惈偺暘巕婡峔丏戞15夞擔杮徚壔婍娻敪惗妛夛憤夛丏2004丆嶥杫丏
22. 憪栰恀挩丆朙揷幚丆楅栘戱丆廐栰岞恇丆嵅乆栘懽巎丆尒揷桾復丆埳搶暥惗丆帪栰棽帄丆崱堜峗嶰丏堓娻DNA儊僠儖壔僾儘僼傽僀儕儞僌偺僋儔僗僞乕夝愅傪梡偄偨専摙丏戞15夞擔杮徚壔婍娻敪惗妛夛憤夛丏2004丆嶥杫丏
23. 忋栰棟巕丆朙揷幚丆廐栰岞恇丆栰搰惓姲丆懞堜惌巎丆尒揷桾復丆嵅乆栘懽巎丆楅栘戱丆墦摗崅晇丆帪栰棽帄丆崱堜峗嶰丏僸僩堓娻偵偍偗傞僫僩儕僂儉僩儔儞僗億乕僞乕僼傽儈儕乕堚揱巕SLC5A8偺堎忢儊僠儖壔偲敪尰梷惂丏戞15夞擔杮徚壔婍娻敪惗妛夛憤夛丏2004丆嶥杫丏
24. 嵅乆栘懽巎丆彫椦庻媣丆抮揷攷丆嶳杮攷岾丆尒揷桾復丆帪栰棽帄丆擔栰揷桾帯丆埳搶暥惗丆崱堜峗嶰丏徚壔婍娻偵偍偗傞ribosomal protein L13堚揱巕偺妶惈壔丏戞15夞擔杮徚壔婍娻敪惗妛夛憤夛丏2004丆嶥杫丏
25. 嵅摗垷桼旤丆朙揷幚丆抮揷塸擵丆楅栘戱丆廐栰岞恇丆尒揷桾復丆帪栰棽帄丆崱堜峗嶰丏戝挵娻偍傛傃堓娻偵偍偗傞HLA-DR偺敪尰徚幐偵偍偗傞Class 嘦transactivator偺僄僺僕僃僱僥傿僢僋側堎忢偺栶妱丏戞15夞擔杮徚壔婍娻敪惗妛夛憤夛丏2004丆嶥杫丏
26. 抮揷攷丆嵅乆栘懽巎丆尒揷桾復丆朙揷幚丆帪栰棽帄丆崱堜峗嶰丏T-fimbrin堚揱巕偺G2/M婜偺僠僃僢僋億僀儞僩傊偺娭梌偲峈娻嵻姶庴惈丏戞15夞擔杮徚壔婍娻敪惗妛夛憤夛丏2004丆嶥杫丏
27. 朙揷幚丆楅栘戱丆廐栰岞恇丆憪栰恀挩丆嵅摗垷桼旤丆懞堜惌巎丆忋栰棟巕丆尒揷桾復丆帪栰棽帄丆崱堜峗嶰丏僄僺僕僃僱僥傿僢僋側堎忢傪昗揑偲偟偨怴偟偄徚壔婍娻帯椕朄偺奐敪丏戞15夞擔杮徚壔婍娻敪惗妛夛憤夛丏2004丆嶥杫丏
28. 朙揷幚丆愇揷掯晇丆嵅摗垷桼旤丆怷杮壚榓丆楅栘戱丆抮揷塸擵丆嵅摗徃巙丆帪栰棽帄丆崱堜峗嶰丏憿寣婍庮釃偵偍偗傞HLA-DR偺敪尰掅壓偵偍偗傞CIITA堚揱巕偺僄僺僕僃僱僥傿僋側堎忢偺栶妱丏戞66夞擔杮寣塼妛夛憤夛丒戞46夞擔杮椪彴寣塼妛夛崌摨憤夛丏2004丆嫗搒丏
29. 楅栘戱丆朙揷幚丆帪栰棽帄丆怷枮丆崱堜峗嶰丏SFRP堚揱巕偺epigenetic側晄妶壔偼戝挵娻偍偗傞Wnt宱楬偺堎忢妶惈壔傪曗姰偡傞丏戞24夞擔杮暘巕庮釃儅乕僇乕尋媶夛丏2004丆暉壀丏
30. 忋栰棟巕丏朙揷幚丆廐栰岞恇丆尒揷桾復丆懞堜惌巎丆嵅乆栘懽巎丆楅栘戱丆墦摗崅晇丆帪栰棽帄丆崱堜峗嶰丏僸僩堓娻偵偍偗傞僫僩儕僂儉僩儔儞僗億乕僞乕僼傽儈儕乕堚揱巕SLC5A8偺堎忢儊僠儖壔偲敪尰梷惂丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
31. 廐栰岞恇丆朙揷幚丆楅栘戱丆憪栰恀挩丆昪戙峃壜丆尒揷桾復丆嵅乆栘懽巎丆崱堜峗嶰丆帪栰棽帄丏RAS僔僌僫儖揱払偵偍偗傞Genetic/Epigenetic堎忢偺夝愅丏戞63夞丂擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
32. 楅栘戱丆朙揷幚丆栰搰惓姲丆廐栰岞恇丆尒揷桾復丆嵅乆栘懽巎丆昪戙峃壜丆憪栰恀挩丆帪栰棽帄丆怷丂枮丏崱堜峗嶰丏戝挵娻偵偍偗傞暘斿宆Frizzled娭楢抈敀堚揱巕偺僄僺僕僃僱僥傿僢僋側晄妶壔偼戝挵娻偵偍偗傞Wnt僔僌僫儖宱楬妶惈壔傪曗姰偡傞丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
33. 嵅乆栘懽巎丏尒揷桾復丆朙揷幚丆愇揷惃捗巕丆嶳壓棙弔丆揷拞晀攷丆拞懞桽曘丏崱堜峗嶰丆帪栰棽帄丏p73揮幨惂屼場巕偵傛傞IL亅4僔僌僫儖偺妶惈壔丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
34. 崱堜悞丆廐栰岞恇丆朙揷幚丆壃榓峅丆慮変晹梲暯丆楅栘戱丆崱堜峗嶰丆暯捤攷媊丆帪栰棽帄丏岥峯滸暯忋旂娻偵偍偗傞RAS娭楢堚揱巕偺僕僃僱僥傿僢僋偍傛傃僄僺僕僃僱僥傿僢僋側堎忢偺夝愅丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
35. 娵嶳楁弿丆朙揷幚丆柧愇峗巎丆惵栘暥晇丆嵅乆栘懽巎丆尒揷桾復丆昪戙峃壜丆奯撪塸庽丆扖枻帯擵丆崱堜峗嶰丆帪栰棽帄丏僸僩偲儅僂僗偺僎僲儉斾妑夝愅偵傛傞怴婯p53昗揑堚揱巕摨掕偺帋傒丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
36. 怷杮堦榊丆懌棫尗嵠丆朙揷幚丆嵅乆栘懽巎丆娵嶳楁弿丆擔栰揷桾帯丆岺摗棽堦丆崱堜峗嶰丆帪栰棽帄丏怴婯p53昗揑堚揱巕偲偟偰偺SCN3B堚揱巕偺摨掕丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
37. 栰搰惓姲丆楅栘戱丆朙揷幚丆廐栰岞恇丆尒揷桾復丆嵅乆栘懽巎丆帪栰棽帄丆崱堜峗嶰丏徚壔娗娻偵偍偗傞SEZ6L堚揱巕偺僄僺僕僃僱僥傿僢僋側晄妶壔丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
38. 懞堜惌巎丆朙揷幚丆嵅摗垷桼旤丆忋栰棟巕丆廐栰岞恇丆楅栘戱丆尒揷桾復丆帪栰棽帄丆崱堜峗嶰丏傾億僩乕僔僗桿摫堚揱巕BNIP3偺僄僺僕僃僱僥傿僢僋側堎忢偲娻偵偍偗傞Hypoxia掞峈惈偺暘巕婡峔丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀.
39. 嵅摗垷桼旤丆朙揷幚丆抮揷塸擵丆楅栘戱丆尒揷桾復丆廐栰岞恇丆嵅乆栘懽巎丆帪栰棽帄丆崱堜峗嶰丏徚壔婍娻偵偍偗傞MHC class II transactivator 偺僄僺僕僃僱僥傿僢僋側堎忢丏 戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
40. 墱揷暯榓丆朙揷幚丆帪栰棽帄丆幏報懢榊丏尗娻偵偍偗傞MCA-RDA朄傪梡偄偨怴婯儊僠儖壔昗揑堚揱巕偺扨棧丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
41. 昪戙峃壜丆搚嵅婭巕丆朙揷幚丆尒揷桾復丆嵅乆栘懽巎丆彫奀峃晇丆崱堜峗嶰丆帪栰棽帄丏峈偑傫嵻墳摎惈儁僾僠僪僼傿儞僈乕僾儕儞僩偺栐梾揑専弌丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
42. 憪栰恀挩丆朙揷幚丆楅栘戱丆廐栰岞恇丆尒揷桾復丆奯撪塸庽丆埳搶暥惗丆崱堜峗嶰丆帪栰棽帄丏堓娻偺DNA儊僠儗乕僔儑儞僾儘僼傽僀儖偺夝愅丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
43. 崅嫶暥旻丆朙揷幚丆懞堜惌巎丆楅栘戱丆尒揷桾復丆嵅乆栘懽巎丆愇揷掯晇丆帪栰棽帄丆崱堜峗嶰丏憿寣婍庮釃偵偍偗傞傾億僩乕僔僗娭楢堚揱巕偺僄僺僕僃僱僥傿僢僋側堎忢偺夝愅丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
44. 朙揷幚丆楅栘戱丆廐栰岞恇丆尒揷桾復丆帪栰棽帄丆崱堜峗嶰丏偑傫偵偍偄偰DNA儊僠儖壔偵傛傝晄妶壔偝傟傞堚揱巕偺栶妱丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
45. 柧愇峗巎, 娵嶳楁弿丆惵栘暥晇丆朙揷幚丆嵅乆栘懽巎丆尒揷桾復丆昪戙峃壜丆扖枻帯擵丆崱堜峗嶰丆帪栰棽帄. p53寢崌攝楍夝愅偺偨傔偺摑崌揑夝愅僔僗僥儉偺奐敪.戞63夞擔杮娻妛夛妛弍憤夛. 2004, 暉壀.
46. 帥郪彑旻丆姦壨峕屽丆朙揷幚丆楅栘戱丆廐栰岞恇丆壃榓峅丆嵅乆栘懽巎丆尒揷桾復丆崱堜峗嶰丆岺摗棽堦丆帪栰丂棽帄丏棏憙娻偵偍偗傞TCF2堚揱巕偺僄僺僕僃僱僥傿僢僋側堎忢. 戞63夞擔杮娻妛夛妛弍憤夛. 2004, 暉壀.
47. 慮変晹梲暯丆朙揷幚丆壃榓峅丆崱堜廆丆楅栘戱丆廐栰岞恇丆崱堜峗嶰丆暯捤丂攷媊丆帪栰棽帄.岥峯滸暯忋旂娻偵偍偗傞堎忢儊僠儖壔偺栐梾揑夝愅.戞63夞擔杮娻妛夛妛弍憤夛. 2004, 暉壀.
48. 壃榓峅丆朙揷幚丆尒揷桾復丆嵅摗垷桼旤丆崱堜峗嶰丆暯捤攷媊丆帪栰棽帄丏M婜僠僃僢僋億僀儞僩堚揱巕傪僞乕僎僢僩偲偟偨岥峯娻嵶朎姅偺壔妛椕朄姶庴惈偺憹嫮丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
49. 尒揷桾復丆朙揷幚丆嵅摗垷桼旤丆壃榓峅丆嵅乆栘懽巎丆昪戙峃壜丆廐栰岞恇丆楅栘戱丆崱堜峗嶰丆帪栰棽帄丏暘楐婜僠僃僢僋億僀儞僩堚揱巕CHFR偺婡擻夝愅丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
50. 抮揷攷丆嵅乆栘懽巎丆尒揷桾復丆朙揷幚丆帪栰棽帄丆崱堜峗嶰丏T-fimbrin堚揱巕偺G2/M婜僠僃僢僋億僀儞僩傊偺娭梌偲峈偑傫嵻姶庴惈丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
51. 擖慏廏恗丆 搉绮屷堦, 惣怷攷岾, 媑揷岾堦, 戝搰梇堦榊, 愳岥揘, 柤墇抭, 榓揷戩榊, 拞懞桽曘, 帪栰棽帄丏Ewing娭楢庮釃偵偍偗傞EWS-ETS梈崌堚揱巕偺昗揑堚揱巕偲偟偰偺儔儈僯儞兝3傾僀僜僼僅乕儉偺摨掕丏戞63夞擔杮娻妛夛妛弍憤夛丏2004丆暉壀丏
52. 擖慏廏恗丆搉绮屷堦, 愳岥揘, 柤墇抭, 榓揷戩榊, 嶳壓晀旻, 媑揷岾堦, 帪栰棽帄, 拞懞桽曘丏EWS-ETS梈崌堚揱巕偺昗揑堚揱巕偲偟偰摨掕偝傟偨儔儈僯儞兝3傾僀僜僼僅乕儉偺婡擻夝愅丏戞37夞擔杮惍宍奜壢妛夛崪丒擃晹庮釃妛弍廤夛丏2004丆搶嫗
53. 尒揷桾復丆朙揷幚丆幁搰棟嵐丆嵅摗垷桼旤丆壃榓峅丆嵅乆栘懽巎丆楅栘戱丆昪戙峃壜丆廐栰岞恇丆崱堜峗嶰丆帪栰棽帄丏暘楐婜僠僃僢僋億僀儞僩暘巕CHFR偺惂屼婡峔偺夝愅丏戞27夞擔杮暘巕惗暔妛夛擭夛丏2004丆恄屗丏
54. 朙揷幚丆楅栘戱丆廐栰岞恇丆憪栰恀挩丆嵅摗垷桼旤丆娵嶳楁弿丆忋栰棟巕丆栰搰惓姲丆帪栰棽帄丆崱堜峗嶰丏僂僀儖僗娭楢庮釃偵偍偗傞DNA儊僠儖壔偺栶妱丏戞27夞擔杮暘巕惗暔妛夛擭夛丏2004丆恄屗丏
55. 栰搰惓姲丆楅栘戱丆朙揷幚丆帪栰棽帄丆崱堜峗嶰丏堓娻偵偍偗傞SFRP堚揱巕偺僄僺僕僃僱僥傿僢僋側晄妶壔丏戞27夞擔杮暘巕惗暔妛夛擭夛丏2004丆恄屗丏
56. 楅栘戱丆朙揷幚丆栰搰惓姲丆帪栰棽帄丆怷枮丆崱堜峗嶰丏SFRP堚揱巕偺僄僺僕僃僱僥傿僢僋側晄妶壔偼僸僩戝挵娻偵偍偗傞Wnt僔僌僫儖宱楬偺妶惈壔傪曗姰偡傞丏戞27夞擔杮暘巕惗暔妛夛擭夛丏2004丆恄屗丏
57. 昪戙峃壜丆嵅乆栘懽巎丆崱堜峗嶰丏拞懞桽曘丆帪栰棽帄丏p53僼傽儈儕乕堚揱巕丆p63丆p73偵傛傞Pigment Epithelium Derived Factor 偺敪尰桿摫丏戞27夞擔杮暘巕惗暔妛夛擭夛丏2004丆恄屗丏
58. 嵅乆栘懽巎丆抮揷攷丆尒揷桾復丆朙揷幚丆帪栰棽帄丆擔栰揷桾帯丆崱堜峗嶰丏傾僋僠儞寢崌抈敀T-fimbrin 偵傛傞G2/M婜惂屼偲峈娻嵻姶庴惈丏戞27夞擔杮暘巕惗暔妛夛擭夛丏2004丆恄屗丏
59. 忋栰棟巕丆朙揷幚丆栰搰惓姲丆廐栰岞恇丆懞堜惌巎丆嵅摗垷桼旤丆嵅乆栘懽巎丆楅栘戱丆壃丂榓峅丆憪栰恀挩丆帪栰棽帄丆崱堜峗嶰丏Pyrosequencing 傪棙梡偟偨DNA儊僠儖壔夝愅朄偺奐敪丏戞27夞擔杮暘巕惗暔妛夛擭夛 2004丆恄屗丏
60. 娵嶳楁弿丆朙揷幚, 柧愇峗巎, 惵栘暥晇丆嵅乆栘懽巎丆尒揷桾復丆奯撪塸庽丆扖枻帯擵, 帪栰棽帄丆崱堜峗嶰丏僸僩偲儅僂僗偺僎僲儉斾妑夝愅偵傛傞怴婯p53昗揑堚揱巕摨掕偺帋傒丏戞27夞擔杮暘巕惗暔妛夛擭夛 2004, 恄屗丏
61. 壃榓峅丄栰岥惤丄朙揷幚丄帪栰棽帄丄暯捤攷媊丏M婜僠僃僢僋億僀儞僩堚揱巕傪僞乕僎僢僩偲偟偨岥峯滸暯忋旂娻偺壔妛椕朄姶庴惈偺憹嫮丂戞58夞擔杮岥峯壢妛夛憤夛儈僯僔儞億僕僂儉丂2004丆墶昹丏
62. 壃榓峅丄栰岥惤丄朙揷幚丄帪栰棽帄丄暯捤攷媊丏岥峯滸暯忋旂娻偵偍偗傞M婜僠僃僢僋億僀儞僩堚揱巕CHFR偺堎忢儊僠儖壔偲microtubule inhibitor姶庴惈丂戞49夞擔杮岥峯奜壢妛夛憤夛丂2004丆愮梩丏
63. 帪栰棽帄丏乽敪僈儞堚揱巕尋媶偵傛傞僈儞懱幙偺夝柧乿丏乽戞54夞擔杮懱幙堛妛夛憤夛乿懱幙堛妛尋廋島嵗乽Common Disease偺懱幙妛-懱幙堛妛偺夝柧傪偳偙傑偱恑傫偱偄傞偐-乿2004. 嶥杫丏

尋媶彆惉

1. 帪栰棽帄丆暯捤攷媊丆栘屗岾宐丏桳巺暘楐僠僃僢僋億僀儞僩堚揱巕CHFR偺岥峯娻恌抐丒帯椕傊偺墳梡丏暯惉16-17擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮婎斦尋媶B乯
2. 帪栰棽帄丏p53偲偦偺昗揑堚揱巕孮偺婡擻夝愅丏暯惉12-16擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮摿掕椞堟尋媶乯
3. 帪栰棽帄丏M婜僠僃僢僋億僀儞僩堚揱巕CHFR傪昗揑偲偟偨旝彫娗慾奞惈峈娻嵻偺姶庴惈恌抐偍傛傃娻帯椕傊偺墳梡丏暯惉16擭搙乮2004擭乯帩揷婰擮尋媶彆惉嬥丏
4. 帪栰棽帄丏桳巺暘楐僠僃僢僋億僀儞僩堚揱巕CHFR傪昗揑偲偟偨旝彫娗慾奞惈峈娻嵻偺姶庴惈恌抐偍傛傃娻帯椕傊偺墳梡丏暯惉16擭搙乮2004擭乯戝嶃娻尋媶夛堦斒妛弍尋媶彆惉嬥丏
5. 嵅乆栘懽巎丆帪栰棽帄丏p53揮幨惂屼場巕僼傽儈儕乕偺嵶朎暘壔偵偍偗傞栶妱丏暯惉16-17擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮摿掕椞堟尋媶乯丏
6. 嵅乆栘懽巎丏DNA懝彎僠僃僢僋億僀儞僩堚揱巕T-fimbrin偺徚壔婍娻恌抐丒帯椕傊偺墳梡丏暯惉16-17擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮婎斦尋媶C乯
7. 嵅乆栘懽巎丏p53揮幨惂屼場巕僼傽儈儕乕偺婡擻夝愅偲娻偺恌抐丒帯椕傊偺墳梡丏嵿抍朄恖崅徏媨斳娻尋媶婎嬥 暯惉16擭搙尋媶幰奀奜弌挘彆惉嬥丏
8. 朙揷幚丄偑傫偺敪惗偲恑揥偵偍偗傞DNA儊僠儖壔偍傛傃僸僗僩儞廋忺堎忢偺栶妱. 暯惉17-21擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮摿掕椞堟尋媶乯.
9. 朙揷幚丄崱堜峗嶰丏僄僺僕僃僱僥傿僢僋側堎忢傪昗揑偲偟偨徚壔婍娻偺怴偟偄帯椕朄偺奐敪丄暯惉15-16擭搙暥晹壢妛徣壢妛尋媶曗彆嬥 (婎斦尋媶 B) .
10. 朙揷幚丏桳巺暘楐僠僃僢僋億僀儞僩堚揱巕CHFR偺偑傫恌抐丒帯椕傊偺墳梡丄撈棫峴惌朄恖丂壢妛媄弍怳嫽婡峔丄暯惉15亅18擭搙 愴棯揑憂憿尋媶悇恑帠嬈丂屄恖宆尋媶 (偝偒偑偗).
11. 朙揷幚.戞15夞擔杮徚壔婍娻敪惗妛夛憤夛丒戞3夞崙嵺徚壔婍敪娻夛媍尋媶彆惉. 嵿抍朄恖嶥杫堛壢戝妛妛弍怳嫽夛暯惉16擭搙妛弍尋媶廤夛媦傃崙嵺岎棳僙儈僫乕奐嵜彆惉
12. 尒揷桾復丏M婜僠僃僢僋億僀儞僩堚揱巕CHFR傪昗揑偲偟偨旝彫娗慾奞嵻姶庴惈恌抐朄偺奐敪丏暯惉16擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮摿掕椞堟尋媶乯丂
13. 尒揷桾復丏旝彫娗慾奞嵻偵斀墳偡傞暘楐婜僠僃僢僋億僀儞僩堚揱巕CHFR偺婡擻夝愅丏暯惉16-17擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮庒庤尋媶B乯.丂
14. 尒揷桾復丆昪戙峃壜丆嵅乆栘懽巎丆帪栰棽帄丆朙揷幚丆崱堜峗嶰丆扖枻帯擵丆戝惣峗暥丆柧愇峗巎丏僨僕僞儖僎僲儉僗僉儍僯儞僌朄偺奐敪偲幘姵堚揱巕尋媶傊偺墳梡-崅惛搙丒崅夝憸搙側栐梾揑僸僩僎僲儉DNA偺掕検揑夝愅丏暯惉15-17擭搙怴僄僱儖僊乕丒嶻嬈媄弍憤崌奐敪婡峔(NEDO) 嶻嬈媄弍尋媶彆惉帠嬈彆惉嬥乮嶻嬈媄弍暘栰乯
15. 楅栘戱丏徚壔婍娻偵偍偗傞Wnt僔僌僫儖揱払宱楬堎忢偺夝柧丏暯惉16擭搙嵿抍朄恖嶥杫堛壢戝妛妛弍怳嫽夛嫵堢尋媶彆惉丏
16. 楅栘戱丏暘斿宆WNT慾奞抈敀傪昗揑偲偟偨戝挵娻偺恌抐丒帯椕朄偺奐敪丏暯惉16擭搙丂僲乕僗僥僢僋嵿抍丂尋媶奐敪彆惉帠嬈乮尋媶奐敪僔乕僘堢惉曗彆嬥乯丏
17. 崱堜峗嶰丄朙揷幚丄嶳杮攷岾丄堚揱巕晄埨掕惈側傜傃偵儊僠儖壔堎忢偵傛傞徚壔婍娻偺敪惗偲偦偺暘巕昗揑帯椕. 暯惉13亅16擭搙暥晹壢妛徣壢妛尋媶曗彆嬥 (婎斦尋媶 S).
18. 嶚寧寬旻丆桳懞壚徍丆嵅乆栘懽巎丆挅巕塸弐丆墶揷弤丆嶳杮寬丏堓偑傫敪徢偵娭梌偡傞堚揱巕偺夝柧丏暯惉13-16擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥乮摿掕椞堟尋媶乯
19. 嬥堜栱塰丄朙揷幚丄偑傫偺憗婜恌抐媦傃梊屻偺梊應傪栚巜偟偨僸僩懡抜奒敪偑傫夁掱偵偍偗傞DNA儊僠儖壔偺曄壔偵娭偡傞尋媶丄暯惉15亅16擭搙岤惗楯摥徣偑傫尋媶彆惉嬥.

庴丂徿

1. 楅栘戱丏SFRP堚揱巕偺epigenetic側晄妶壔偼戝挵娻偵偍偗傞Wnt宱楬偺堎忢妶惈壔傪曗姰偡傞丏戞24夞擔杮暘巕庮釃儅乕僇乕尋媶夛彠椼徿丏2004丏
2. 楅栘戱丏戝挵娻偵偍偗傞DNA儊僠儖壔傪巜昗偲偟偨怴偨側娻梷惂堚揱巕偺摨掕偲偦偺婡擻夝柧丏戞63夞擔杮娻妛夛彠椼徿丏2004.